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ENNIGERLOH - The pharmaceutical industry’s demand for continuous processes is increasing because it offers clear advantages such as cost savings, process robustness and no scale-up hurdles.
Continuous dry granulation is now often the process of choice for large-volume or moisture-sensitive products. L.B. Bohle meets this growing demand by offering the new Bohle dry granulator BRC 100, an innovative variable gap granulator. With the introduction of the BRC 100, L.B. Bohle now serves customer needs for all available granulation techniques in the industry.
The BRC 100 enables high-production capacity with minimal loss of material. This is achieved by fast and precise control of the compaction force with a new electromechanical spindle drive for the two rollers. In combination with a sensitive control of the variable gap via the screw feeding system, constant ribbon properties are assured over a wide production range from <1 kg up to 200 kg/h.
Sophisticated equipment design facilitates easy handling and shortens mounting procedures during working shifts. A hygienic design and properly integrated cleaning nozzles allow an effective wash in place process (WIP).
The BRC 100 achieves ribbon granulation with the Bohle Turbo Sieve (BTS 200). The conical sieve design allows gentle particle size reduction at low sieve speeds, which is also applicable at high material throughputs. A variety of different sieve types make it flexible for different product and ribbon properties.
The BRC 100 meets Quality by Design requirements with its functional GMP design,, as well as with its ability to implement different PAT tools.
The advantages of the new Bohle BRC 100 – Dry granulator
© L.B. Bohle Maschinen + Verfahren GmbH / BulkInside
This article is published by L.B. Bohle Maschinen + Verfahren GmbH
L.B. Bohle Maschinen + Verfahren GmbH is a global acting manufacturer for the pharmaceutical industry. The range of products includes process and handling equipment for the pharmaceutical solids production. For instance, film coater, blending systems, ...View company page